Ehlers-Danlos Syndrome (EDS) is a group of inherited disorders affecting the connective tissues that provide strength and elasticity to the skin, joints, and blood vessels.

It is distinct from Hypermobility Spectrum Disorders (HSD), which involve symptoms related to increased joint mobility but do not meet the stricter diagnostic criteria for EDS.

Individuals with EDS often have overly flexible joints and stretchy, fragile skin, which can lead to joint dislocations or sprains, often accompanied by pain.

In some cases, symptoms such as pain, fatigue, dizziness, constipation, and headaches are attributed to EDS or HSD when no other clear explanation is found.

If medical evaluations do not identify any disease or injury, or if treatments fail to provide expected improvement, it is likely that the brain plays a role in generating or contributing to the pain or illness. This is called a neuroplastic symptom.